MK2 inhibitory peptide delivered in nanopolyplexes prevents vascular graft intimal hyperplasia
نویسندگان
چکیده
منابع مشابه
Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury.
BACKGROUND Autologous vein grafts and balloon angioplasty are still commonly used for arterial reconstructive procedures. Their success is limited by the development of intimal hyperplasia (IH). Biliverdin (BVD), one of the by-products of heme degradation, has been shown to have potent antioxidant and antiinflammatory effects. We hypothesized that BVD administration would protect vascular tissu...
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Venous bypass grafts often fail following arterial implantation due to excessive smooth muscle cells (VSMC) proliferation and consequent intimal hyperplasia (IH). Intercellular communication mediated by Connexins (Cx) regulates differentiation, growth and proliferation in various cell types. Microarray analysis of vein grafts in a model of bilateral rabbit jugular vein graft revealed Cx43 as an...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2015
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.aaa4549